2019, Número 2
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Rev Educ Bioquimica 2019; 38 (2)
El papel de las GalNac-Transferasas en el desarrollo del cáncer de mama
García CLM, Hernández JJ, Fernández RB, Hernández CPA, Pérez CME, Gallegos VIB
Idioma: Español
Referencias bibliográficas: 28
Paginas: 48-56
Archivo PDF: 357.72 Kb.
RESUMEN
El cáncer de mama es la segunda causa de muerte de mujeres en el mundo, sin
embargo, si es diagnosticado oportunamente puede ser curado. Recientemente se
ha observado que cambios en la estructura de los oligosacáridos de membrana,
se relacionan con los procesos de transformación y proliferación celular, los cuales
pueden originar el cáncer de mama. La glicosilación incompleta de glicoproteínas,
expone nuevos antígenos, particularmente el antígeno Thomsen-Friedenreich (TF),
Para la síntesis de este antígeno las células emplean enzimas denominadas glicosiltransferasas,
especialmente las GalNac transferasas que adicionan el monosacárido
GalNac a un residuo de serina o treonina. En esta revisión nos enfocaremos en el
papel de las GalNac transferasas, en el desarrollo del cáncer de mama.
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